Research Interests: Dr. D. Michael Denbow

Specific areas of interest include food intake regulation, dietary effects on behavior, and dietary requirements of turkey breeders. Considerable research has been conducted on the role of various neurotransmitters on food intake regulation within the brain, and how diet can influence these neurotransmitter levels and thereby alter behavior.

Such studies involve injection of neurotransmitters directly into the central nervous system and measurement of neurotransmitter levels in response to various manipulation. In addition, studies have been conducted to examine how dietary energy and protein requirements are affected by stage of reproduction and strain in turkeys.

Finally, research is currently in progress to address environmental concerns. The effects of dietary supplementation with phytase has shown that this enzyme can decrease phosphorus excretion while increasing phosphorus digestibility. Further studies are investigating whether the gene for this enzyme can be placed directly in feedstuffs and result in improved nutrient availability.

Recent Publications:

Choi, Y-H., N. Ohno, J. Okumura, D. M. Denbow, and M. Furuse, 1997. Effects of intracerebroventricular injection of               clonidine and neuropeptide Y on food intake in the chicken. Jap. Poultry Sci. 34:58-92.

Parker, J. S., R. K. Flory, D. E. Everhart, and D. M. Denbow, 1996. Case Report: Neurochemnical, physiological, and              behavioral effects of bright light therapy on a corically blind patient. Intern. J. Neurosci. 88:273-282.

Li, J., C.E. Hegeman, R. W. Hanlon, G. H. Lacy, D. M. Denbow, and E. A. Grabau, 1997. Secretion of active recombinant              phytase from soybean cell suspension cultures. Plant Physiol. 114:1103-1111.

Choi, Y-H., N. Ohno, D. M. Denbow, J-I. Okumura and M. Furuse, 1997. Effect of inhibition of nitric oxide synthase on food              intake of chicks fed diets differeing in arginine content. Jap. Poultry Sci. 34:292-298.

Qian, H. E. T. Kornegay, and D. M. Denbow, 1997. Utilization of phytate phosphorus and calcium as influenced by microbial              phytase, cholecalciferol, and the calcium:total phosphorus ratio in broiler diets. Poutlry Sci. 76:37-46.

Denbow, D. M., E. A. Grabau, G. H. Lacy, E. T. Kornegay, D. R. Russell, and P. F. Umbeck, 1998. Soybeans transformed         with a fungal phytase gene imporve phosphorus availability for broilers. Poultry Sci. 77:878-881.

Denbow, D. M., N. Snapir, and M. Furuse, 1999.  Inhibition of food intake by CRF in chickens.  Physiol. Behav.66:645-649.

Bungo, T, M. Shimojo, Y. Masuda, Y-H Choi, D. M. Denbow, and M. Furuse, 1999.  Induction of food intake by a noradrenergic system using clonidine and fusaric acid in the neonatal chick.   Brain Res. 826:313-316.

Zhang, Z. B., E. T. Kornegay, D. M. Denbow, H. P. Veit, and C. T. Larson, 2000.  Comparison of genetically engineered microbial and plant phytase for young broilers.  Poultry Sci. 79:709-717.

 Bungo, T.  Y-H. Choi, D. M. Denbow, M. Shimojo, Y. Masuda, and M. Furuse, 2000.  Intracerebroventricularly                    administered neuropeptide Y and clonidine: Effects on feeding behavior in the neonatal chick. Jap. J. Poultry              Sci. 37:27-32

 Kawakami, S-i., T. Bungo, A. Ohgushi, M. Shimojo, Y. Masuda, D. M. Denbow, and M. Furuse, 2000.  Brain-derived mast cells could mediate histamine-induced inhibition of food intake in neonatal chicks.  Brain Res. 857:313-316.

 Denbow, D. M., S. Meade, A. Robertson, J. P. McMurtry, M. Richards, and C. Ashwell, 2000.  Leptin induced decrease in              food intake in chickens.  Physiol. Behav. 69:359-362.

 Bungo, T.  Y-H. Choi, M. Shimojo, Y. Masuda, D. M. Denbow, and M. Furuse, 2000.  A nitric oxide synthase inhibitor attenuates neuropeptide Y- and clonidine-induced feeding in the neonatal chick.  J. Appl. Animal Res. 17:257-264.

 Furuse, M., T. Bungo, R. Ao, R. Ando, M. S., Y. Masuda, and D. M. Denbow, 2000. Involvement of central gastrin and cholecystokinin in the regulation of food intake in the neonatal chick.  J. Appl. Anim. Res. 18:129-136.

 Zhang, Z. B., E. T. Kornegay, and D. M. Denbow, 2000.  Evalutation of phytase and non-starch polysaccharide enzymes              added alone and in combination on nutrient utilization of individual mixtures of feedstuffs with adult cecectomized              roosters.  Poultry Sci. 79:709-717.

 Ohgushi, A., T. Bungo, M. Shimojo, Y. Masuda, D. M. Denbow, and M. Furuse, 2001.  Relationships between feeding and              locomotion behaviors after central administration of CRF in chicks.   Physiol. Behav. 72:287-289.

 Bungo, T., S.-I. Kawakami, A. Ohgushi,  K. Sashihara, N. Saito, K. Sugahara, S.Hasegawa, D.M. Denbow, and M. Furuse, 2001. Intracerebroventricular injection of fusaric acid attenuates the anorexia by glucagon-like peptide-1 in the neonatal chick. Pharmacol. Biochem. Behav. 70:251-255.

Sashihara, K., M. Miyamoto, A. Ohgushi, D. M. Denbow, and M. Furuse, 2001.  Influence of ketone body and the inhibition of fatty acid oxidation on food intake.  British Poultry Science 42:405-408. 

 Meade, S., D. M. Denbow, 2001.  Feeding, drinking and temperature responses of chickens to intracerebroventricular              histamine.  Physiol. Behav. 73:65-73.

 Zhang, R, T. Nakanishi, A. Ohgushi, R. Ando, T. Yoshimatsu, D. M. Denbow, and M. Furuse, 2001. Suppression of food intake induced by corticotropin-releasing factor family in neonatal chicks.  European Journal of Pharmacology 427:37-41.

 Kwawakami, S.-I., R. Ando, T. Bungo, A. Ohgushi, D. M. Denbow, and M. Furuse, 2001.  Central administration of              BIBP3226, Neuropeptide Y (NPY) Y1 receptor antagonist, does not inhibit fasting- and MPY-induced food intake in              neonatal chicks.  Poultry Science38:259-265.

 Furuse, M., T. Tachibana, A. Ohgushi, R. Ando, T. Yoshimatsu, and D. M. Denbow, 2001.  Intracerebroventricular injection of ghrelin and growth hormone releasing factor inhibits food intake in neonatal chicks.  Neuroscience Letters 301:123-126.

 Liu, D., and D. M. Denbow, 2001.  Maternal dietary lipids modify composition of bone lipids and ex vivo PGE2 production             in early postnatal Japanese quail.  Poultry Sci. 80:1344-1352

Ohgushi, A., T. Nakanishi, T. Bungo, D. M. Denbow, and M. Furuse, 2001.  Effect of conjugated linoleic on                               isolation-induced distress behavior in chicks.  Animal Science Journal 72:427-430.

 Ando, R., S-i. Kawakami, T. Bungo, A. Ohgushi, T. Takagi, D. M. Denbow, and M. Furuse, 2001.  Feeding responses to              several neuropeptide Y receptor agonists in the neonatal chick.  European Journal of Pharmaocology 427:53-59.

Zhang, R., T. Nakanishi, A. Ohgushi, R. Ando, T. Yoshimatsu, D. M. Denbow, and M. Furuse, 2001.  Interaction of corticotropin-releasing factor and glucagon-like peptide-1 on behaviors in chicks.  European J. Pharmacol. 430:73-78.

 Ohgushi, A., T. Yamashita, K. Sashihara, D. M. Denbow, and M. Furuse, 2001.   Influence of intrayolk administration of              docosahexaenoic acid on behavior of chicks after hatching.  Animal Science Journal 72:494-497.

 Kuo, A. Y., J. C. Lee, P. B. Siegel, and D. M. Denbow, 2001.   Differential cardiovascular effects of pharmacological agents              in chickens selected for high and low body weight.  Physiol. Behav. 74:573-579.


E-mail: DENBOWDM@VT.EDU

Phone:  (540)231-6843       

FAX: (540) 231-3713


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Revision Date: 1 March, 2002