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Honglin Jiang |
Education:
- B.S. in Biology:
- M.S. in Veterinary Medicine:
- Ph.D. in Animal Science:
- Postdoctoral Training in Molecular Biology: University of Missouri, 1997-2000
Research Interests:
I am interested in the molecular mechanisms by which growth-stimulating hormones (growth hormone and IGF-I) and nutrients regulate animal growth and metabolism. A better understanding of these mechanisms may help to develop novel strategies to improve animal production efficiency and human health. Current research focuses include: 1) Mechanism of growth hormone regulation of gene expression; 2) Mechanism of nutritional regulation of growth hormone action and IGF-I production; 3) Mechanism of regulatory effects of short-chain fatty acids; 4) Role of miRNAs in animal growth and metabolism. I conduct research in cattle, mouse models and appropriate cell systems. Current research funding includes USDA NRI and NIH grants.
Teaching Interests:
Advanced Animal Physiology; Endocrinology.
Selected Publications:
Jiang, H., Wang, Y.,
Wu, M., Gu, Z., Frank, S. J.
and Torres-Diaz, R. 2007. Growth hormone
stimulates hepatic expression of bovine growth hormone receptor mRNA through
STAT5-activation of a major growth hormone receptor gene promoter. Endocrinology 148:3307–3315.
Gu, Z., Eleswarapu, S. and Jiang, H. 2007. Identification and characterization of microRNAs from the bovine adipose tissue and mammary gland. FEBS Letters 581:981–988.
Xu, Q., Springer, L., Merchant, J. L. and Jiang, H., 2006. Identification of zinc finger binding protein 89 (ZBP-89) as a transcriptional activator for a major bovine growth hormone receptor promoter. Molecular and Cellular Endocrinology 251:88–95.
Chia, D. J., Ono, M., Woelfle, J., Schlesinger-Massart, M., Jiang, H. and Rotwein, P. 2006. Characterization of distinct Stat5b binding sites that mediate growth hormone-stimulated IGF-I gene transcription. The Journal of Biological Chemistry 81:3190–3197.
Wang, Y. and Jiang, H. 2005. Identification of a distal stat5-binding DNA region that may mediate growth hormone regulation of insulin-like growth factor-I gene expression. The Journal of Biological Chemistry 280:10955–10963.
Eleswarapu, S. and Jiang, H. 2005. Growth hormone regulates the expression of hepatocyte nuclear factor-3 gamma and other liver-enriched transcription
factors in the bovine liver. Journal of Endocrinology 184:95–105.
Xu, Q., Walther, N. and
Jiang, H. 2004. Chicken ovalbumin upstream promoter
transcription factor II (COUP-TFII) and hepatocyte
nuclear factor 4gamma (HNF-4gamma) and HNF-4alpha regulate the bovine growth
hormone receptor 1A promoter through a common DNA element. Journal of Molecular
Endocrinology 32:947–961.
Jiang, H., Whitworth, K. M., Bivens, N. J., Ries, J. E.,
Woods, R. J., Forrester, L. J., Springer, G. K., Mathialagan,
N., Agca, C., Prather, R. S. and Lucy, M. C. 2004. Large-scale generation and analysis of
expressed sequence tags from porcine ovary. Biology of Reproduction 71:1991–2002.
Wang, Y., Eleswarapu, S., Beal, W. E., Swecker, W. S., Akers, R. M. and Jiang, H. 2003. Reduced serum insulin-like growth factor (IGF) I is associated with reduced liver IGF-I mRNA and liver growth hormone receptor mRNA in food-deprived cattle. The Journal of Nutrition 133:2555–2560.
Jiang,
H. and Lucy, M. C. 2001. Involvement of hepatocyte nuclear factor-4 in the expression of the growth
hormone receptor 1A messenger ribonucleic acid in bovine liver. Molecular Endocrinology 15:1023–1034.
Jiang,
H., Okamura, C. S. and Lucy, M. C. 1999. Isolation and
characterization of a novel promoter for the bovine growth hormone receptor
gene. The Journal of Biological Chemistry 274:7893–7900.
Email: hojiang@vt.edu
Phone: (540) 231-1859
Fax: (540) 231-3010
Lab: (540) 231-2411