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Mark Cline


2005, Ph.D., Neurochemical Regulation of Behavior.  Virginia Tech
2002, M.S., Reproductive Physiology.  Virginia Tech
1999, B.S., Animal and Poultry Science, Virginia Tech
1996, Assoc., Arts and Sciences,  Blue Ridge Community College

ALS 2304, Anatomy and Physiology

The overarching goal of my research program is to explain appetite regulation and to inspire the next generation of neurobiologists. Our group studies neurotransmitters that are associated with the perception of hunger and satiety with a particular interest at the diencephalon and myelencephalon level. The animal models we most commonly use are chicks including those from lines that have undergone selection for body weight. These lines consist of anorexic and obese individuals. From an agricultural standpoint, the results of our research may contribute to increased production efficiencies in chickens. Our research findings may also eventually contribute to the pharmacological cure for anorexia or obesity in a variety of species, including humans. We were the first to report the appetite-associated roles of six neurotransmitters in any species and we have contributed to the elucidation of other mechanisms of appetite adjustment.

Newmyer, BA, W Nandar, RI Webster, EI. Gilbert, PB Siegel, MA Cline.  2013.  Neuropeptide Y is associated with changes in appetite-associated hypothalamic nuclei but not food intake in a hypophagic avian model. Behavioural Brain Research. 236:327-331. 

 

Cline, MA, M. Furuse. 2012.  Neuropeptide regulation of food intake in chicks. In:Food Intake:Regulation, Assessing and Controlling" JL Morrison, Ed. ISBN:978-1-61324-183-7.  

 

Newmyer, BA, MA Cline. 2011. Neuropeptide AF is associated with short-term reduced food intake in rats. Behavioural Brain Research. 219:351-353.  

 

Smith, ML, BP Prall, PB Siegel, MA Cline. 2011. The threshold of insulin-induced hypophagia is lower in chicks selected for low rather than high juvenile body weight. Behavioural Brain Research. 216:719-722. 

 

Katayama, S, K Shigemi, MA Cline, M Furuse. 2011. Clorgyline Inhibits Orexin-A-Induced Arousal in Layer-Type Chicks. The Journal of Veterinary Medical Science. 73:471-474. 

 

Tachibana T, MA Cline, MSI Kham, H Ueda, K Hiramatsu. 2011. Feeding responses to central administration of several somatostatin analogs in chicks.Comparative Biochemistry and Physiology. 158:47-51. 

 

Tachibana T, K Matsuda, H Sawa, A. Mikami, H. Ueda, MA Cline. 2011. Differential thresholds of neuromedins B-, C-, and bombesin-induced anorexia and crop-emptying rate in chicks. General and Comparative Endocrinology. 169:144-150. 

 

Cline, MA, Siders, R, Newymer, BA, Smith, ML, PB Siegel. 2010. Both calcitonin and calcitonin gene-related peptides' thresholds of hypophagia are considerably lower in chicks selected for high rather than low juvenile body weight. Physiology and Behavior. 101:254-259. 

 

Newymer, BA, PB Siegel, MA Cline. 2010. Neuropeptide AF differentially affects anorexia in lines of chickens selected for high or low body weight. Journal of Neuroendocrinology. 22:593-598. 

 

Cline, MA, SA Cofield, T Tachibana. 2010. Central litorin injection is associated with primary anorexigenic effects that coincide with activation of the magnocellular division of the paraventricular nucleus. Neuropeptides. 44:247-252. 

 

Cline, MA, W, Nandar, C, Bowden, W, Calchary, M, Smith, B Prall; B Newmyer, JO Rogers, PB Siegel. 2010. The threshold of amylin-induced anorexia is lower in chicks selected for low compared to high juvenile body weight. Behavioural Brain Research. 208:650-654. 

 

Katayama S, K Shigemi, MA Cline, M. Furuse. 2010. Intracerebroventricular injection of orexin-A stimulates monoamine metabolism but not HPA axis in neonatal chicks. Neuroscience letters. 484:157-161. 

 

Tachibana T, K Matsuda, SI Khan, H Ueda, MA Cline. 2010. Feeding and drinking response following central administration of neuromedin S in chicks. Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology. 157:63-67. 

 

Katayama, S, K Hamasu, Shigemi, MA Cline, M. Furuse, 2010. Intracerebroventricular injection of orexin-A, but not orexin-B, induces arousal of layer-type neonatal chicks. Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology. 157:132-135. 

 

Tachibana, T, K Matsuda, SI Khan, H Ueda, MA Cline. 2010. Feeding and drinking response following central administrations of bombesin-like peptides in chicks. Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology. 156: 394-399. 

 

Tachibana, T, MS Khan, K Matsuda, H Ueda, MA Cline. 2010. Central administration of substance P inhibits feeding behavior in chicks. Hormones and Behavior. 57: 203-208. 

 

Smith, ML, NA Kohart, BA Newmyer, MA Cline. 2009. Gamma(2)-melanocyte stimulating hormone decreases food intake in chicks. Neuroscience Letters. 465:210-213. 

 

Cline, MA, JE Layne, WA Calchary, RS Sheehy, T Tachibana, M Furuse. 2009. LPLRFamide causes anorexigenic effects in broiler chicks and bobwhite quail. General and Comparative Endocrinology. 165:315-320. 

 

Cline, MA, B Newymer, ML Smith. 2009. The anorectic effect of neuropeptide AF is associated with satiety-related hypothalamic nuclei. Journal of Neuroendocrinology. 21:595-601. 

 

Newymer, BA, MA Cline. 2009. Neuropeptide SF is associated with reduced food intake in chicks. Behavioural Brain Research. 205: 311-314. 

 

Cline, MA, Prall, B, JO Rogers, T Tachibana. 2009. Satiety induced by central stresscopin is mediated by corticotrophin-releasing factor receptors and hypothalamic changes in chick. Pharmacology Biochemistry and Behavior. 92:663-639. 

 

Tachibana, T, MA Cline, K Sugahara, H Ueda, K Hiramatsu. 2009. Central administration of somatostatin stimulates feeding behavior in chicks. General and Comparative Endocrinology. 161:354-349. 

 

Tachibana, T, K Sugahara, H Ueda, MA Cline. 2009. Role of adrenergic alpha-2-receptors on feeding behavior in layer-type chicks. General and Comparative Endocrinology. 161:407-411.  Cline, MA, L Silwa. 2009. Neuropeptide VF-associated satiety involves mu and kappa but not delta subtypes of opioid receptors in chicks. Neuroscience Letters. 455:195-198. 

 

Layne, JL, KE Hunt, T True, RS Gill, RE. Combos, MA Cline. 2009. Central calcitonin exerts anoretic effects via the hypothalamus in chicks. Pharmacology Biochemistry and Behavior. 92:433-438. 

 

Cline, MA, A Kuo, M Smith, W Nandar BC Prall, PB Siegel, D.M. Denbow. 2009. Differential food intake responses to central corticotrophin releasing factor in lines of chickens divergently selected for low or high body weight. Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology. 152:130-134. 

 

Cline, MA, W Calchary W Nandar. 2009. Effect of calcitonin gene-related peptide (CGRP) on avian appetite-related processess. Behavioural Brain Research. 196: 242-247. 

 

Cline, MA, D Mathews. 2009. Anoretic effects of neuropeptide FF are mediated via central mu and kappa subtypes of opioid receptors and receptor ligands. General and Comparative Endocrinology. 159:125-129. 

 

Prall, B, MA Cline. 2008. Anorexigenic effects of central neuropeptide K are associated with hypothalamic changes in juvenile Gallus gallus. General and Comparative Endocrinology. 159:130-135. 

 

Cline, MA, W Nandar, C. Bowden, PP Hein, MD Denbow, PB Siegel. 2008. Differential feeding responses to central alpha-melanocyte stimulating hormone in genetically low and high body weight selected lines of chickens. Life Sciences. 83: 208-231. 

 

Cline MA, CN Bowden, WA Calchary, JE Layne. 2008. Short-term anorexigenic effects of central neuropeptide VF are associated with hypothalamic changes in chicks. Journal of Neuroendocrinology 20:971-977. 

 

Cline MA, BC Prall, ML Smith, WA Calchary PB Siegel. 2008. Differential appetite-related responses to central neuropeptide S in lines of chickens divergently selected for low or high body weight. Journal of Neuroendocrinology 20:904-908. 

 

Nandar, W, J Milligan MA Cline. 2008. Mechanisms of xenin‐induced anorectic response in chicks (Gallus gallus). General and Comparative Endocrinology. 157:58-62. 

 

Cline MA, D Fouse, BC Prall 2008. Central and peripheral alytesin cause short-term anorexigenic effects in neonatal chicks. Neuropeptides. 42:283-291..

 

Cline, MA, CN Bowden, W. Nandar, JO Rogers. 2008. Central oxyntomodulin causes anorexigenic effects associated with the hypothalamus and alimentary canal in chicks (Gallus gallus). Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 149:405-410. 

 

Cline MA, W Nandar, ML Smith, BH Pittman, M Kelly, JO Rogers. 2008. Amylin causes anorexigenic effects via the hypothalamus and brain stem in chicks. Regulatory Peptides. 146:140-146. 

 

Smith ML, B. Prall, W Nandar, MA Cline. 2008 Beta-melanocyte stimulating hormone potently reduces appetite via the hypothalamus in chicks. Journal of Neuroendocrinology. 20:220-226. 

 

Cline MA, W Nandar, B Prall, C Bowden, DM Denbow. 2008. Central visfatin causes orexigenic effects in chicks. Behavioural Brain Research. 186:293-297. 

 

Cline MA, W Nandar JO Rogers. 2007. Central neuropeptide FF reduces feed consumption and affects hypothalamic chemistry in chicks. Neuropeptides. 41:433-439. 

 

Cline MA, DC Godlove, W Nandar, CN Bowden, BC Prall. 2007. Anorexigenic effects of central neuropeptide S involve the hypothalamus in chicks (Gallus gallus). Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology.148:657-663. 

 

Cline MA, ML Smith. 2007. Central alpha-melanocyte stimulating hormone attenuates behavioral effects of neuropeptide Y in chicks. Physiology and Behavior. 91:588-592.  

 

Cline MA, W Nandar, JO Rogers. 2007. Xenin reduces feed intake by activating the ventromedial hypothalamus and influences gastrointestinal transit rate in chicks. Behavioural Brain Research. 179:28-32.