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D. Michael Denbow

Professor

Avian Physiology, Neuropharmacology


Ph.D., 1980, N.C. State University

• Purina Mills Award for Teaching Excellence, 1996.

• Wine Award for Teaching Excellence, 2003

• Teaching Award of Merit, National Association of Colleges and Teachers of Agriculture, 2004

• ALS 2304  Anatomy and Physiology

• APSC 3304  Embryology

• UH 3304  Nutrition, Brain and Behavior

• UH 3304 Chinese Medicine

• ALS/BIOL 4554  Neurochemical Regulation

My research focuses on the neurochemical regulation of food intake in chickens, emphasizing how selection for body weight alters the neurochemical mechanisms within the central nervous system. These studies have been directed towards understanding how long-term selection for either high or low body weight has altered the neurochemical mechanisms within the brain controlling intake. Recently, I have also been investigating whether herbs have potential for replacing traditional antibiotics in poultry diets. We are specifically investigating whether plants known to have antibiotic activity are effective against poultry pathogens and whether they can improve growth when added to poultry diets. In addition, we are beginning a new area of research, determining if selection for growth has altered the gut microflora.

  1. Zhang, R., T. Tachibana, T. Takaki, T. Koutoku, D. M. Denbow, and M. Furuse, 2004.  Serotonin modified the corticotropin-releasing factor induced behaviors of chicks.  Behavioural Brain Res. 151:47-52.
  2. Tachibana, T. Ei-S. Saito, S. Saito, S. Tomonaga, D. M. Denbow, M. Furuse, 2004.  Comparison of brain arginine-vasotocin and corticotrophin-releasing factor for physiological responses in chicks.  Neuroscience Lett. 360:165-169.
  3. Saito S, T. Takagi, T. Koutoku, E-s. Saito, H. Hirakawa, S. Tomonaga, T. Tachibana, D. M. Denbow and M. Furuse, 2004.  Differences in catecholamine metabolism and behaviour in neonatal broiler and layer chicks.  Brit. Poultry Sci. 45:158-162.
  4. Tomonaga S, T. Tachibana, T. Takagi, E-S. Saito, R. Zhang R, D. M. Denbow, and M. Furuse, 2004.  Effect of central administration of carnosine and its constituents on behaviors in chicks. Brain Res. Bull. 63: 75-82.
  5. Liu, D., H. P. Veit, and D. M. Denbow, 2004.  Effects of long-term dietary lipids on mature bone mineral content, collagen, cross-links and PGE2 production in Japanese quail.  Poult. Sci. 83:1876-1883.
  6. Saito, E-S., H. Kaiya, T. Tachibana, S. Tomonaga, D. M. Denbow, K. Kangawa, and M. Furuse, 2005.  Inhibitory effect of ghrelin on food intake is mediated by the corticotropin-releasing factor system in neonatal chicks. Regulatory Peptide 125:201-208.
  7. Koga, Y., H. Takahashi, D. Oikawa, T. Tachibana, T., D. M. Denbow, and M. Furuse, 2005.  Brain creatine functions to attenuate stress responses through GABAnergic system in chicks.  Neuroscience 132:65-71.
  8. Kuo, A. Y., M. A. Cline, E. Werner, P. B. Siegel, and D. M. Denbow, 2005.  Leptin effects on food and water intake in chickens selected for high and low body weight.  Physiol. Behav. 84:459-464.
  9. Takahashi, H., K. Ando, T. Tachibana, D. M. Denbow and M. Furuse, 2005.  Regulation of body temperature by thyrotropin releasing hormone in neonatal chicks.  Developmental Brain Research 157:58-64.
  10. Takahashi, H., K. Ando, T. Tachibana, D. M. Denbow and M. Furuse, 2005.  Regulation of body temperature by thyrotropin releasing hormone in neonatal chicks.  Developmental Brain Research 157:58-64.
  11. Tomonaga, S., Y. Kaji, T. Tachibana, D. M. Denbow, and M. Furuse, 2005. Oral administration of b-alanine modifies carnosine contents of the muscle and brain in chicks.  Anim. Sci. J. 76:249-254.
  12. Koutoku, T., H. Takahashi, S. Tomonaga, D. Oikawa, S. Saito, T. Tachibana, L. Han, L., K. Hayamizu, K., D. M. Denbow, and M. Furuse, 2005.  Central administration of phosphatidylserine attenuates isolation stress induced behavior in chicks.  Neurochem. Intern. 47:183-189.
  13. Saito, S., E-Suke Saito, T. Tachibana, D. M. Denbow, and Mitsuhiro Furuse, 2005.  ICV CRF and isolation differentially enhance plasma corticosterone concentrations in layer- and meat-type neonatal chicks. Comp. Biochem. Physiol. Part A 141:305-309.
  14. Saito S., T. Tachibana, Y-H. Choi, D. M. Denbow, M. Furuse, 2005.  ICV melatonin reduces acute stress responses in neonatal chicks.   Behav. Brain Res. 165:197-203.
  15. Takagi, T, Y-H. Choi, T. Tachibana, D. M. Denbow, and M. Furuse, 2005.  Effect of intracerebroventricular injection of L-pipecolic acid on GABA concentrations in brain sites of neonatal chicks.  J. Appl. Anim. Res. 28(1):9-13.
  16. Abbasnejad. M., H. Jonaidi, D. M. Denbow, and A. M. Pour Rahimia, 2005.  Feeding and locomotion responses to centrally injected nociceptin/orphanin FQ in chicks.  Physiol. Behav. 85:383-386.
  17. Adachi, N., S. Tomonaga, T. Tachibana, D. M. Denbow, M. Furuse, 2006.  (-)-Epigallocatechin gallate attenuates acute stress responses through GABAergic system in the brain. European J. Pharmacol. 531:171-175.
  18. Emoto, F., S. Tomonaga, T. Tachibana, D. M. Denbow, and M. Furuse, 2006.  Effect of centrally administered sphingomyelin on food intake and HPA axis of chicks.  J. Appl. Animal. Res. 29:91-96.
  19.  Asechi, M., S. Tomonaga, T. Tachibana, L. Han, K. Hayamizu, D. M. Denbow, M. Furuse, 2006.  Intracerebroventricular injection of L-serine analogs and derivatives induces sedative and hypnotic effects under an acute stressful condition in neonatal chicks.  Behavioural Brain Research 170:71-77.
  20.  Tomonaga, S., K. Kanedko Y. Kaji, D. M. Denbow, and M. Furuse, 2006.   Dietary b-alanine enhances brain, but not muscle, carnosine and anserine concentrations in broilers.  Animal Sci. J. 77:79-86.
  21.  Kuo, A. Y., J. C. Lee, P. B. Siegel, and D. M. Denbow, 2006.  The differential autonomic nervous system response in obese and anorexic chickens (Gallas gallas).  Comp. Biochem. Physiol. 144:359-364.
  22. Kurauchi, I.  M. Asechi, T. Tachibana, L. Han, K. Hayamizu, D. M. Denbow, M. Furuse, 2006.  Intracerebroventricular injection of L-alanine induces a sedative effect under an acute stressful condition in neonatal chicks.  Journal of Poultry Science 43:384-387.
  23. Tachibana, T., H. Kaiya, D. M. Denbow, K. Kangawa, and M. Furuse, 2006.  Central ghrelin acts as an anti-dipsogenic peptide in chicks.  Neuroscience Letters 405:241-245
  24. Tachibana, T., H. Takahashi, D. Oikawa, D. M. Denbow, and M. Furuse, 2006.  Thyrotropin-releasing hormone increased heat production without the involvement of corticotrophin-releasing factor in neonatal chicks. Pharm. Biochem. Behav. 83:528-532.
  25. Tajalli, S., H. Jonaidi, M. Abbasnejad, and D.M. Denbow, 2006.  Interaction between Nociceptin/Orphanin FQ (N/OFQ) and GABA in response to feeding.  Physiol. Behav.89:410-413.
  26. Kurauchi, I.,M. Asechi, T. Tachibana, L. Han, K. Hayamizu, D. M. Denbow, M. Furuse, 2007.  Intracerebroventricular injection of tryptophan, but not lysine and methionine, induces a sedative effect under an acute stressful condition in neonatal chicks.  Journal of Applied Animal. 31:25-28.
  27. Tomonaga, S., K. Noda, R. Suenaga, M. Asechi, N. Adachi, K. Kino, A. Nakamura, D. M. Denbow, and M. Furuse, 2007.  Stress responses in neonatal meat- and layer-types of neonatal Nagoya chicks.  Animal Science Journal 78:541-545.
  28. Adachi, N., S. Tomonaga, R. Suenaga, D. M. Denbow, and M. Furuse, 2007.  Galloyl group is not necessary for a sedative effect of catechin through GABAergic system.  Letters in Drug Design & Discovery 4:163-167.
  29. Yamane H. S. Tomonaga, R.Suenaga, D. M. Denbow,M. Furuse, 2007.  Intracerebroventricular injection of glutathione and its derivative induces sedative and hypnotic effects under an acute stress in neonatal chicks.  Neuroscience Letters 418:87-91
  30. Yang, S. J., and D. M. Denbow, 2007.  Interaction of leptin and nitric oxide on food intake in broilers and Leghorns.  Physiol. Behav. 92:651-657.
  31. Furuse, M., S. Tomonaga, Y. Tsuneyoshi, H. Yamane, and D. M. Denbow, 2007.  Neuropeptidergic regulation of food intake in the neonatal chick: A Review.  J. Poultry Sci. 44:349-356
  32. Yamane, H., S. Tomonaga, R. Suenaga, D. M. Denbow, M. Furuse. 2007.  Intracerebroventricular injection of glutathione and its derivative induces sedative and hypnotic effects under an acute stress in neonatal chicks.  Letters in Drug and Discovery 4:368-372.
  33. Yamane, H., S. Tomonaga, R. Suenaga, D. M. Denbow, M.Furuse, 2007.  Intracerebroventricular injection of glutathione suppresses food intake of neonatal chicks.  Journal of Animal and Veterinary Advances 6:1247-1249.
  34. Haraguchi, T., S. Tomonaga, I. Kurauchi, K. Hamasu, D. M. Denbow and M. Furuse, 2007.  Intracerebroventricular injection of L-proline modifies food intake in neonatal chicks.  Journal of Animal and Veterinary Advances 6:1255-1257.
  35. Suenaga R., S. Tomonaga, H. Yamane, I. Kurauchi, Y. Tsuneyoshi, H. Sato, D. M. Denbow, M. Furuse, 2007.   Intracerebroventricular injection of L-arginine induces sedative and hypnotic effects under an acute stress in neonatal chicks.  Amino Acids 35:139-146.
  36. Adachi, N., Y-H. Choi, R. Suenaga, S. T. D. M. Denbow, and M. Furuse, 2007.  Green tea component, (-)-epigallocatechin gallate, but not L-threanine, has sedative effects in chick under acute stress conditions.  Current Topics in Nutraceutical Research 5:107-110.
  37. Zhao, J., A.F. Harper, M.J. Estienne, K.E. Webb Jr., A.P. McElroy and D.M. Denbow. 2007. Growth performance and intestinal morphology responses in early weaned pigs to supplementation of antibiotic-free diets with an organic copper complex and spray-dried plasma protein in sanitary and nonsanitary environments. Journal of Animal Science 85:1302-1310.
  38. Tsuneyoshi, Y., S. Tomonaga, H. Yamane, K. Morishita, D. M. Denbow ,and M.Furuse, 2008.  Central administration of L-Ser-L-His and L-Ile-L-His induced sedative effects under an acute stressful condition in chicks.  Letters in Drug Design & Discovery 5:65-68.
  39. Cline, M. A., W. Nandar, B. C. Prall, C. N. Bowden, and D. M. Denbow, 2008. Central visfatin causes orexigenic effects in chicks. Behavioural Brain Research 186:293-297.
  40. Yamane, H., D.M. Denbow, and M. Furuse, 2008.  Regulation of stress responses by peptides and small nitrogenous compounds in neonatal chicks.  Avian Poultr. Biol. Rev. 18:107-122.
  41. Asechi, M., S. Tomonaga, T. Tachibana, L. Han, K. Hayamizu, D. M. Denbow, M. Furuse, 2008.  Relationships between the sedative and hypnotic effects of intracerebroventricular administration of L-serine and its metabolites, pyruvate and the derivative amino acids in the neonatal chick under an acute stressful conditions. Amino Acids 34:55-60
  42. Sato, M., S. Tomonaga, D. M. Denbow, M. Furuse, 2008.  Changes in free amino acids in the brain during embryonic development in layer and broiler chickens.  Amino Acids (in press)
  43. Suenaga R, Tomonaga S, Yamane H, Kurauchi I, Tsuneyoshi Y, Sato H, Denbow DM, Furuse M (2008) Intracerebroventricular injection of L-arginine induces sedative and hypnotic effects under an acute stress in neonatal chicks.  Amino Acids 35:139-146.
  44. Suenaga R, Yamane H, Tomonaga S, Asechi M, Adachi N, Tsuneyoshi Y, Kurauchi I, Sato H, Denbow DM, Furuse M (2008) Central L-arginine reduced stress responses are mediated by L-ornithine in neonatal chicks. Amino Acids 35:107-113.
  45. Tsuneyoshi, Y., H. Yamane, S. Tomonaga, K. Morishita, D. M. Denbow, M. Furuse, 2008. Reverse structure of carnosine-induced sedative and hypnotic effects in the chick under acute stress.  Life Sciences 82  1065–1069
  46. Cline, M. A., W. Nandar, P. P. Hein, D. M. Denbow, and P. B. Siegel, 2008.  Differential feeding responses to central alpha-melanocyte stimulating hormone in genetically low and high body weight select lines of chicks.  Life Sci. 83:208-213.
  47. Hamasu, K., T. Haraguchi, Y. Kabuki, N. Adachi, S. Tomonaga, H. Sato, D. M. Denbow, and M. Furuse, 2008.  L-Proline is a sedative regulator of acute stress in the brain of neonatal chicks. 
  48. Yamane, H., M. Asechi, Y. Tsuneyoshi, I.  Kurauchi, D. M. Denbow, and M. Furuse, 2008.  Intracerebroventricular injection of L-aspartic acid and L-asparagine induces sedative effects under an acute stressful condition in neonatal chicks.  Animal Sci. J. (In Press)
  49. Cline, M. A., A. Y. Kuo, M. L.Smith, P. B. Siegel, and D. M. Denbow, 2008.  Differential feed intake responses to central corticotrophin releasing factor in lines of chickens divergently selected for low or high body weight.  Comp. Biochem. Physiol. 152: 130-134
  50. Shigemi, K., Y. Tsuneyoshi, K. Hamasu, L. Han, K. Hayamizu, D. M. Denbow, M. Furuse, 2008. L-Serine induces sedative and hypnotic effects acting at GABAA receptors in neonatal chicks. European Journal of Pharmacology 599:86-90.
  51. Hamasu, K., K. Shigemi, Y. Tsuneyoshi, H. Yamane, H. Sato, D. M. Denbow, and M. Furuse, 2008. Intracerebroventricular injection of L-proline and D-proline induces sedative and hypnotic effects by different mechanisms under an acute stressful condition in chicks.  Amino Acids 37:377-382.
  52. Akers, R. M., and D. M. Denbow, 2008.  Anatomy and Physiology of Domestic Animals.  Wiley-Blackwell, Ames Iowa
  53. Yamane, H., D. M. Denbow, and M. Furuse, 2009.  Screening dipeptides having central functions for excitation and sedation. Mini-Reviews in Medicinal Chemistry 9:300-3005.
  54. Yamane, H., I. Kurauchi, D. M. Denbow, and M. Furuse, 2009. Central functions of amino acids for the stress response in chicks.  Asian-Aust. J. Animal Sci. 22:296-304.
  55. Kurauchi, I., H. Yamanea, Y. Tsuneyoshia, D. M. Denbow, M. Furuse, 2009. Central L-alanine reduces energy expenditure with a hypnotic effect under an acute stressful condition in neonatal chicks.  Amino Acids 36:131-135.
  56. Hamasu, K., K. Shigemia, Y. Kabukia, S. Tomonagaa, D. M. Denbow, M. Furuse, 2009.  Central L-proline attenuates stress-induced dopamine and serotonin release from the chick forebrain. Neuroscience Letters 460:78-81.
  57. Sato, M. S. Tomonaga, D. M. Denbow, and M. Furuse, 2009.  Changes in free amino acids in the brain during embryonic development in layer and broiler chickens.  Amino Acids 36:303-308.
  58. Yamane, H., M. Asechi, Y. Tsuneyoshi, I. Kurauchi, D. M. Denbow, and M. Furuse, 2009.  Intracerebroventricular injection of L-aspartic and L-asparagine induces sedative effects under an acute stressful condition in neonatal chicks.  Animal Sci J. 80:286-290.
  59. Yamane, H., S. Tomonaga, Y. Tsuneyoshi, D. M. Denbow, and M. Furuse, 2009.  Reduced glutathione decreases energy expenditure in chicks exposed to separation stress.  Animal Sci. J. 80:291-295. 
  60. Kurauchi, I., K. Hamasu, D.M. Denbow, and M. Furuse, 2009.  Plasma amino acid concentration in neonatal chicks modified by acute stress.  J. Animal and Veterinary Advances 8:1838-1841.
  61. Tsuneyoshi, Y., M. Sato, S. Tomonaga, H. Yamane, K. Morishita, D. M. Denbow, and M.Furuse, 2009.  Oral administration of Excitin-1 (β-alanyl-L-leucine) alters behaviors and brain monoamine and amino acid concentrations in rats.  Nutritional Neuroscience 12:175-181.
    Mike Denbow

  • (540) 231-6843
  • (540) 231-3010 (Fax)
  • denbowdm@vt.edu
  • Animal and Poultry Sciences (0306)
    3250 Litton Reaves Hall, Virginia Tech
    175 West Campus Dr.
    Blacksburg, VA 24061