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Samer El-Kadi


Ph.D., Animal Science, 2006, University of Maryland

M.S., Poultry Science, 2000, American University of Beirut, Lebanon

Diploma, Agriculture Engineer, 1998, American University of Beirut, Lebanon

B.S., Agriculture, 1998, American University of Beirut, Lebanon

My research interest is primarily to elucidate the underlying factors that contribute to macronutrient metabolism. My research is centered on two areas. One research area has focused on understanding why amino acids are catabolized excessively by splanchnic tissues (mainly liver and intestines), and whether dietary or physiologic factors such as amino acid supplies or muscle growth could affect their metabolism. To get insight into the partitioning of amino acids to anabolic and catabolic pathways we are using the multi-catheterized ruminant model and primary epithelial cell culture in combination with stable isotope dilution and 13C-mass isotopomer distribution analysis (13C-MIDA) techniques. Another area has focused on investigating the in vivo regulation of protein turnover in growing pigs. To achieve this goal we are applying a multifaceted approach that combines protein expression and targeted metabolite analyses to measure protein synthesis and degradation in muscles. The immediate objectives are to improve our understanding of how amino acids are utilized and how protein synthesis and degradation are controlled in the growing animal. The overarching goal is to identify areas where novel dietary or management interventions could be used to enhance growth and improve the efficiency with which amino acid are deposited in muscles.

Wheatley SM, El-Kadi SW, Suryawan A, Boutry C, Orellana RA, Nguyen HV, Davis SR, Davis TA. Protein synthesis in skeletal muscle of neonatal pigs is enhanced by administration of β-hydroxy-β-methylbutyrate. Am J Physiol Endocrinol Metab. 2014, 306: E91-99.

Boutry C, El-Kadi SW, Suryawan A, Wheatley SM, Orellana RA, Kimball SR, Nguyen HV, Davis TA. Leucine pulses enhance skeletal muscle protein synthesis during continuous feeding in neonatal pigs. Am J Physiol Endocrinol Metab. 2013, 305: E620-631.

El-Kadi SW, Gazzaneo MC, Suryawan A, Orellana RA, Murgas-Torrazza R, Wilson FA, Srivastava N, Nguyen HV, Fiorotto ML, Kimball SR, and Davis TA. Muscle and Viscera Protein Synthesis in Neonatal Pigs Is Increased More by Intermittent Bolus than Continuous Feeding. Ped Res. 2013, 74: 154-162.

Holder VB, El-Kadi SW, Tricarico JM, Vanzant ES, McLeod KR, Harmon DL. The effects of crude protein concentration and slow release urea on nitrogen metabolism in Holstein steers. Arch Anim Nutr. 2013, 67: 93-103.

El-Kadi SW, Suryawan A, Srivastava N, Orellana RA, Nguyen HV, Lobley GE, and Davis TA. Anabolic signaling and protein deposition are enhanced by intermittent as compared with continuous feeding in skeletal muscle of neonates. Am J Physiol - Endocrinol Metab. 2012, 302: E674-686.

Suryawan A, Murgas Torrazza R, Gazzaneo MC, Orellana RA, Nguyen HV, Fiorotto ML, El-Kadi SW, and Davis TA. Enteral leucine supplementation increases protein synthesis in skeletal and cardiac muscles and visceral tissues of neonatal pigs through mTORC1-dependent pathway. Ped Res. 2012, 71: 324-331.

Gazzaneo MC, Suryawan A, Orellana RA, Murgas Torrazza R, El-Kadi SW, Wilson FA, Kimball SR, Srivastava N, Nguyen HV, Fiorotto ML, and Davis TA. Intermittent bolus feeding has a greater stimulatory effect on protein synthesis in skeletal muscle than continuous feeding in neonatal pigs. J Nutr. 2011, 141: 2152-2158.

Murgas Torrazza R, Suryawan A, Gazzaneo MC, Orellana RA, Frank JW, Nguyen HV, Fiorotto ML, El-Kadi SW, and Davis TA. Leucine supplementation of a low-protein meal increases skeletal muscle and visceral tissue protein synthesis in neonatal pigs by stimulating mTOR-dependent translation initiation. J Nutr. 2010, 140: 2145-2152.

Koontz A, El-Kadi SW, Harmon DL, Vanzant ES, Matthews J, Boling J, and McLeod KR. Effect of ractopamine on whole body and splanchnic energy metabolism in Holstein steers. Can J Anim Sci. 2010, 90: 77-85.

El-Kadi SW, Baldwin RL VI, McLeod KR, Sunny NE, Owens SL, and Bequette BJ. Glutamate is the major anaplerotic substrate in the tricarboxylic acid cycle of isolated rumen epithelial and duodenal mucosal cells from beef cattle. J Nutr. 2009, 139: 869-875.

El-Kadi SW, McLeod KR, Elam NA, Kitts SE, Taylor CC, Harmon DL, Bequette BJ, and Vanzant ES. Quantitative assessment of nutrient metabolism by the portal-drained viscera in beef steers consuming graded amounts of forage. J Anim Sci. 2008, 86: 1-11.

Sunny NE, Owens SL, Baldwin RL VI, El-Kadi SW, Kohn RA, and Bequette BJ. Salvage of blood urea nitrogen in sheep is highly dependent upon plasma urea concentration and the efficiency of capture within the digestive tract. J Anim Sci. 2007, 85: 1006-1013.

El-Kadi SW, Baldwin RL, Sunny NE, Owens SL, and Bequette BJ. Intestinal protein supply alters amino acid, but not glucose, metabolism by the sheep gastrointestinal tract. J Nutr. 2006, 136: 1261-1269.

Bequette BJ, Sunny NE, El-Kadi SW, and Owens SL. Application of stable isotopes and mass isotopomer distribution analysis to the study of intermediary metabolism of nutrients. J Anim Sci. 2006, 84: E50-59.

    Samer El-Kadi