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David E. Gerrard

Meat Science/Muscle Biology


Ph.D., Muscle Biology, 1992, Purdue University

M.S., Animal Sciences, 1985, Purdue University

B.S., Animal Sciences, 1983, Purdue University

 

• Outstanding Research Award, AMSA 2007

• University Faculty Scholar, Purdue University, 2002-2007

• ESCOP/ACOP Leadership Development Fellow, 2002-2003

• Achievement Award, AMSA (awarded to scientists in the first 10 years of their career for outstanding achievement in meat science/muscle biology), 2000

The overall goal of Dr. Gerrard’s laboratory is to maximize the production of high quality meat. Three distinct yet related approaches have been utilized to attain this goal. Ongoing studies range from understanding the basic biochemistry involved in the transformation of muscle into meat, to applied studies involving technology transfer for monitoring fresh meat quality. In addition, Dr. Gerrard’s research includes fundamental studies focused on understanding muscle growth and development, which directly affects ultimate meat quality. This multidisciplinary approach to meat science spans several domestic and international laboratories.

  1. Bowker*, B.C., D. R. Swartz, A. L. Grant, and D. E. Gerrard.  2005. Myosin heavy chain isoform composition influences the susceptibility of actin-activated S1 ATPase and myofibrillar ATPase to pH inactivation. Meat Sci. 71(2):342-350.
  2. Freese*, L.G., C. Rehfeld, R. Fuerbass, G. Kuhn, C.S. Okamura, K. Ender, A.L. Grant and D.E. Gerrard.  2005.  Exogenous somatotropin alters IGF axis in porcine endometrium and placenta. D. Anim. Endo. 29(3):457-475.
  3. Rehfeldt, C., G. Ott, D.E. Gerrard, L. Varga, W. Schlote, J.L. Williams, U. Renne and L. Bunger.  2005.  Effects of the compact mutant myostatin allele Mstn (Cmpt-dl1Abc) introgressed into a high growth mouse line on skeletal muscle cellularity. J. Muscle Res. Cell Mot. 26(2-3):103-12.
  4. Selby*, T.L., A. Berzins, A.K. Bhunia, A.L. Grant, D.E. Gerrard and R.H. Linton 2006.  Microbial heat resistance of listeria monocytogenes and the impact on ready-to-eat meat quality after post-package pasteurization Meat Sci.  74:425-434.
  5. Wang*, X., G.H. Hockerman, H.W. Green, C.F. Babbs, S.I. Mohammad, D.E. Gerrard, M.A. Latour, B. London, K.M. Hannon and A.L. Pond.  2006.  Merg1a K+ channel induces skeletal muscle atrophy by activating the ubiquitin-proteasome pathway. FASEB J. 20(9):1531-1533.
  6. Guo*, Q, B.T. Richert, J.R. Burgess, D.D. Hall, D.M. Webel, D.E. Orr, Jr., M. Blair, G. Fitzner, A. L. Grant and D.E. Gerrard.  2006.  Effects of dietary vitamin E and fat supplementation on pork quality J. Anim. Sci. 84: 3071-3078.
  7. Guo*, Q., B.T. Richert, J.R. Burgess, D. Webel, D. Orr, M. Blair, A.L. Grant and D.E. Gerrard. 2006. Effect of dietary vitamin E supplementation and feeding period on pork quality J. Anim. Sci. 84: 3089-3099.
  8. Copenhafer*, T.L., B.T. Richert, A.P. Schinckel, A.L. Grant, and D.E. Gerrard.  2006.  Augmented postmortem glycolysis does not occur early postmortem in AMPKγ3-mutated porcine muscle of halothane positive pigs. Meat Sci. 73(4) 590-599.
  9. Xia*, J., A.D. Weaver*, D.E. Gerrard and G. Yao. 2006.  Monitoring sarcomere structure changes in whole muscle with diffuse light reflectance.  J Biomed Opt. 11(4):040504.
  10. Best, L.G., E. Gilbert-Barness, D.E. Gerrard, A. Gendron-Fitzpatrick and J.M. Opitz.  2006. "Double-muscle" trait in cattle: a possible model for Wiedemann-Beckwith syndrome. Fetal Ped. Pathol. 25(1):9-20.
  11. Gunawan*, A.M., S.K. Park*, J.M. Pleitner, L. Feliciano, A.L. Grant and D.E. Gerrard.  2006.  Myosin heavy chain isoform gene expression reflects contractile protein content.  J. Anim. Sci. 85(5):1247-56.
  12. Eash*, J., A. Olsen, G. Breur, D. Gerrard and K. Hannon.  2007.  FGFR1 inhibits skeletal muscle atrophy associated with hindlimb suspension.  BMC Musculoskelet Disord. 8:32.
  13. Gunawan*, A.M., B.T. Richert, A.P. Schinckel, A.L. Grant and D.E. Gerrard 2007.  Ractopamine induces differential gene expression in porcine skeletal muscles.  J. Anim. Sci. 85(9):2115-24.
  14. Shi*, H., C. Zeng A. Ricome, K.M. Hannon, A.L. Grant and D.E. Gerrard.  2007.  Extracellular signal-regulated kinase pathway is differentially involved in beta-agonist-induced hypertrophy in slow and fast muscles.  Am J Physiol Cell Physiol. 292(5):C1681-9.
  15. Scheffler*, T.L. and D.E. Gerrard.  2007.  Mechanisms controlling pork quality development: The biochemistry controlling postmortem energy metabolism.  Meat Science 77(1):7-16
  16. Xia*, J., A. Weaver*, D.E. Gerrard and G. Yao. 2008.  Heating induced optical property changes in beef muscle.  J. Food Eng. 84(1):75-81.
  17. Gunawan*, A.M., B.T. Richert, A.P. Schinckel, A.L. Grant and D.E. Gerrard   Ractopamine-induced fiber type-specific gene expression in porcine skeletal muscles is independent of growth. J. Anim. Sci. 85(9):2115-24.
  18. Shen*, Q.W., D.E. Gerrard and M. Du.  2008.  Compound C, an inhibitor of AMP-activated protein kinase, inhibits glycolysis in mouse Longissimus Dorsi postmortem. Meat Sci. 78(3) p. 323-330.
  19. Xia*, J., A. Weaver*, D.E. Gerrard, and G. Yao. 2008.  Heating induced optical property changes in beef muscle J. Food Eng. 84(1) p. 75-81.
  20. Weaver*, A.D., B.C. Bowker, and D.E. Gerrard.  Sarcomere length influences postmortem proteolysis of excised bovine semitendinosus muscle.  J. Animal Science 86(8):1925-32.
  21. Shi*, H., J.M. Pleitner, J.M. Scheffler, C. Zeng K.M. Hannon, A.L. Grant and D.E. Gerrard.  2008.  Modulation of skeletal muscle fiber type by mitogen-activated protein kinase signaling. FASEB J. 22(8):2990-3000.
  22. Xia*, J., Weaver*, A., Gerrard, D. E., & Yao, G. (2008b). Distribution of optical scatteringproperties in four beef muscles. Sensing and Instrumentation for Food Quality and Safety, 2, 75–81.
  23. Park*, S., T.L. Scheffler*, A.M. Gunawan*, H. Shi*, C. Zeng*, K.M. Hannon, A.L. Grant and D.E. Gerrard.  2009.  Chronic elevated calcium blocks AMPK-induced GLUT-4 expression in skeletal muscle. Amer. J. Physiol. 296(1):C106-15.
  24. Iglay*, H.B., J.W. Apolzan, D.E. Gerrard, J.K. Eash, J.C. Anderson and W.W. Campbell.  2009. Moderately increased protein intake predominately from egg sources does not influence whole body, regional, or muscle composition responses to resistance training in older people.  The Journal of Nutrition, Health & Aging. 13(2):108-14.
  25. Weaver,* A.D., B.C. Bowker, A.L. Grant and D.E. Gerrard.  2009.  Sarcomere length influences mu-calpain-mediated proteolysis of bovine myofibrils.  J. Anim. Sci. 87(6):2096-103.
  26. Shi*, H., J.M. Pleitner, J.M. Scheffler, C. Zeng K.M. Hannon, A.L. Grant and D.E. Gerrard.  Mitogen-activated protein kinase signaling is necessary for the maintenance of muscle mass.  Amer. J. Physiol. 296(5):C1040-8.
  27. Gunn*, J.P., A.D. Weaver*, R.P. Lemenager, D.E. Gerrard, M.C. Claeys and S. L. Lake.  Effects of dietary fat and crude protein on feedlot performance, carcass characteristics, circulating plasma metabolites, and meat quality in steers fed differing levels of distiller’s dried grains with solubles.  J. Anim. Sci 87(9):2882-90.
  28. Park*, S.K, A. M. Gunawan*, T. L. Scheffler*, A. L. Grant and D. E. Gerrard.  2009. Myosin heavy chain isoform content and energy metabolism can be uncoupled in pig skeletal muscle J. Anim. Sci 87(2):522-31.
  29. Park*, S.K. T. L. Scheffler*, M. E. Spurlock, A. L. Grant and D. E. Gerrard 2009. Chronic activation of 5’-AMP-activated protein kinase changes myosin heavy chain expression in growing pigs J. Anim. Sci 87(10):3124-33.
  30. Depreux*, F.F.S, A.L. Grant, C.A. Bidwell and D.E. Gerrard. 2010. Molecular cloning and characterization of porcine calcineurin-alpha subunit delta isoform expression in skeletal muscle.  J Anim Sci. 88(2):562-71.
  31. Ranasinghesagara*, J., T.M. Nath*, S.J. Wells*, A.D. Weaver*, D.E. Gerrard, and G. Yao. 2010. Imaging optical diffuse reflectance in beef muscles for tenderness prediction Meat Sci. 84(3):413-21.
  32. Weaver*, A.D., B.C. Bowker, and D.E. Gerrard.  Muscle stretching influences proteolysis of beef myofibrils.  J. Anim. Sci 87(6):2096-103.
  33. Gunn*, P.J., R.P. Lemenager, M.C. Claeys, D.E. Gerrard, D.R. Buckmaster and S.L. Lake. 2010. Glycerin improves feedlot performance of early weaned steer consuming a distiller’s grain-based diet. J. Anim. Sci.  87(9):2882-90
  34. Ranasinghesagara*, J., T.M. Nath*, S.J. Wells*, A.D. Weaver*,* D.E. Gerrard and G. Yao. 2010.  Imaging optical diffuse reflectance in beef muscles for tenderness prediction Meat Science 84:413–421.
  35. Dilger*, A.C., M.E. Spurlock, A.L. Grant and D.E. Gerrard.  2010. Myostatin null mice respond differently to dietary-induced and genetic obesity. Anim Sci J. 81(5):586-93.
  36. Zhao*, D., A. Pond, B. Watkins, D. Gerrard, Y. Wen, S. Kuang and K. Hannon.  2010. Peripheral endocannabinoids regulate skeletal muscle development and maintenance European Journal Translational Myology - Basic Applied Myology 1 (4): xxx-xxx
  37. Park*, S.K. T.L. Scheffler*, J.M. Scheffler and D.E. Gerrard. 2011. Chronic high levels of cytosolic calcium decreases AICAR-induced AMPK activity via calcium/calmodulin activated protein kinase II signaling cascade in muscle. Cell Calcium (accepted).
  38. Scheffler*, T.L., Park, S.K. and D.E. Gerrard. 2011. Lessons to learn about postmortem metabolism using the AMPK gamma 3 mutation: the RN pig. Meat Science (accepted).
  39. Fisher*, Kimberly D., Tracy L. Scheffler, Steven C. Kasten, Brad M. Reinholt, Gregory R. van Eyk, Jeffery Escobar, Jason M. Scheffler, and David E. Gerrard*.  2011.  Dietary manipulation causes childhood obesity-like characteristics in pigs.  J. Nutr. (submitted).
    Dave Gerrard

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