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Eric A Wong

Professor

Molecular Biology


Postdoctorate, Biology, 1981-1986, University of Utah

Ph.D., Biology, 1981, University of California, San Diego

B.S., Biology, 1976, Massachusetts Institute of Technology

Courses Taught

• ALS/Biol 2404  Biotechnology in a Global Society

• ALS 3104  Animal Breeding and Genetics

• APSC 5004  Graduate Seminar

• APSC/PPWS 5044  Biotechnology in Agriculture and Society

• ALS/Bchm/Biol/PPWS 6024  Topics in Molecular Cell Biology and Biotechnology

The transport of nutrients (e.g., amino acids, peptides and sugars) across the intestinal epithelia is mediated by membrane bound transporter proteins, which play an important role in regulating growth. In particular, we are interested in the peptide transporter, PepT1, which transports di- and tripeptides.  We have found that developmental age and dietary treatment can alter expression of the chicken PepT1 gene.  Currently, we are examining the expression profiles of PepT1 and other nutrient transporters in the yolk sac membrane and the intestine during embryonic development. 

Coccidiosis is the major parasitic disease of poultry caused by the intestinal protozoan Eimeria.  Infections by Eimeria parasites cause destruction of intestinal epithelia, resulting in compromised nutrient absorption, reduced feed efficiency and body weight gain, and subsequent severe economic losses for the poultry industry.  We are investigating the molecular mechanism for Eimeria infection of intestinal epithelial cells.  We are examining the role that liver expressed antimicrobial peptide-2 (LEAP-2) plays in modulating Eimeria infection.

Wu, G.Q., Siegel, P.B., Gilbert, E.R., Yang, N., and Wong, E.A.  2011.  Expression profiling of somatotropic axis genes in lines of chickens divergently selected for 56-day body weight.  Animal Biotech (in press)

Gilbert, E.R., Cox, C.M., Williams, P.M., McElroy, A.P., Dalloul, R.A., Ray, W.K., Barri, A., Emmerson, D.A., Wong, E.A., and Webb, K.E. Jr.  2011. Eimeria species and genetic background influence the serum protein profile of broilers with coccidiosis.  PLoS One 6: e14636.

Casterlow, S., Li, H., Gilbert, E.R., Dalloul, R.A., McElroy, A.P., Emmerson, D.A., and Wong, E.A.  2011. An antimicrobial peptide is downregulated in the small intestine of Eimeria maxima-infected chickens.  Poult. Sci. (in press)

Madsen, S.L. and Wong, E.A. 2011. Expression of the chicken peptide transporter one and the peroxisome proliferator-activated receptor alpha following feed restriction and subsequent refeeding. Poult. Sci (in press)

Gilbert, E., Williams, P., Ray, W., Li, H., Emmerson, D., Wong, E., and Webb, K. 2010. Proteomic evaluation of chicken brush-border membrane during the early post-hatch period. J. Proteome Res. 9: 4628-4639.

Gilbert, E.R., Li, H., Emmerson, D.A., Webb, K.E. Jr., and Wong, E.A. 2010. Dietary protein composition influences abundance of peptide and amino acid transporter mRNA in the small intestine of two lines of broiler chicks. Poult. Sci. 89: 1663-1676.

Stewart, R.L., Scaglia, G., Abaye, A.O., Swecker, W.S. Jr., Wong, E.A., McCann, M.A., and Fontenot, J.P. 2010. Tall fescue copper and copper-zinc superoxide dismutase status in beef steers grazing three different fescue types. Prof. Anim. Sci. 26:489-497.

Frazier, S., Ajiboye, K., Olds, A. Wyatt, T., Luetkemeier, E.S. and Wong, E.A.  2008. Functional characterization of the chicken peptide transporter 1 (PepT1, SLC15A1) gene. Anim. Biotech. 19:201-210.

Li, H., Gilbert, E.R., Zhang,Y., Crasta, O., Emmerson, D., Webb Jr., K.E., and Wong. E.A. 2008.  Expression profiling of the solute carrier gene family in the chicken intestine from the late embryonic to early post hatch stages. Anim. Genet. 39:407-424.

Gilbert, E.R., Wong, E.A. and Webb Jr., K.E.   2008. Board-invited review: Peptide absorption and utilization: Implications for animal nutrition and health. J. Anim. Sci. 86:2135-2155.

Mott, C.R., Siegel, P.B., Webb, Jr., K.E. and Wong. E.A.  2008. Gene expression of nutrient transporters in the small intestine of chickens from lines divergently selected for high or low juvenile body weight. Poult. Sci. 87:2215-2224.

Zhao, J., Harper, A., Webb, Jr., K.E., Kuehn, L.A., Gilbert, E. Xiao, X. and Wong, E.A.  2008. Cytokine mRNA expression in the small intestine of weanling pigs fed diets supplemented with specialized protein or peptide source. Asian-Aust. J. Anim. Sci. 21:1800-1806.

Carlier, P.R., Anderson., T.D., Wong, D.M., Hsu, D.C., Hartsel, J., Ma, M., Wong, E.A., Choudhury, R., Lam, P.C-H., Totrov, M.M., and Bloomquist. J.R.  2008. Towards a species-selective acetylcholinesterase inhibitor to control the mosquito vector of malaria, Anopheles gambiae. Chemico-Biolog. Inter. 175:368-375.

Gilbert, E.R., Li, H., Emmerson, D.A., Webb, K.E. Jr., and Wong, E.A. 2008.  Dietary protein quality and feed restriction influence abundance of nutrient transporter mRNA in the small intestine of broilers.  J. Nutr. 138: 262-271.

Gilbert, E.R., Li, H., Emmerson, D.A., Webb, K.E. Jr., and Wong, E.A. 2007.  Developmental regulation of nutrient transporter and enzyme mRNA abundance in the small intestine of broilers.  Poult. Sci. 86: 1739-1753.

Gilbert, E.R., E.A. Wong, Vaughan, M., and K.E. Webb, Jr. 2007. Distribution and abundance of nutrient transporter mRNA in the intestinal tract of the black bear, Ursus americanus. Comp. Biochem. Physiol, part B 146: 35-41.

    Eric Wong

  • (540) 231-4737
  • (540) 231-3010 (Fax)
  • (540) 231-3183 (Lab)
  • ewong@vt.edu
  • 3150 Litton Reaves
    Blacksburg, VA 24061