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Eric A Wong

Professor

Molecular Nutrition


Postdoctorate, Biology, 1981-1986, University of Utah

Ph.D., Biology, 1981, University of California, San Diego

B.S., Biology, 1976, Massachusetts Institute of Technology

Courses Taught

• ALS/Biol 2404  Biotechnology in a Global Society

• ALS 3104  Animal Breeding and Genetics

• APSC/PPWS 5044  Biotechnology in Agriculture and Society

 

The transport of nutrients (e.g., amino acids, peptides and sugars) across the intestinal epithelia is mediated by membrane bound transporter proteins, which play an important role in regulating growth. In particular, we are interested in the peptide transporter, PepT1, which transports di- and tripeptides.  We have found that developmental age and dietary treatment can alter expression of the chicken PepT1 gene.  Currently, we are examining the expression profiles of PepT1 and other nutrient transporters in the yolk sac membrane and the intestine during embryonic development. 

Coccidiosis is the major parasitic disease of poultry caused by the intestinal protozoan Eimeria.  Infections by Eimeria parasites cause destruction of intestinal epithelia, resulting in compromised nutrient absorption, reduced feed efficiency and body weight gain, and subsequent severe economic losses for the poultry industry.  We are investigating the molecular mechanism for Eimeria infection of intestinal epithelial cells.  We are examining the role that liver expressed antimicrobial peptide-2 (LEAP-2) plays in modulating Eimeria infection.

Weintraut, M., Kim, S., Dalloul, R., and Wong, E.A. 2016. Expression of small intestinal nutrient transporters in embryonic and posthatch turkeys. Poult. Sci. 95: 90-98.

 

Yin, H., Sumners, L.H., Dalloul, R.A. Miska, K.B. Fetterer, R.H. Jenkins, M.C. Zhu, Q. and Wong, E.A. 2015. Expression of an antimicrobial peptide, digestive enzymes and nutrient transporters in the intestine of E. praecox-infected chickens. Poult. Sci. 94:1521-1526.

 

Miska, K.B., Fetterer, R.H. and Wong, E.A. 2015. The mRNA expression of amino acid transporters, aminopeptidase, and the di- and tri-peptide transporter PepT1 in the intestine and liver of post-hatch broiler chicks. Poult. Sci. 94:1323-1332.

 

Su, S., Miska, K.B., Fetterer, R.H., Jenkins, M.C., and Wong, E.A. 2015. Expression of digestive enzymes and nutrient transporters in Eimeria-challenged broilers.  Exp. Parasitol. 150:13-21.

Zhang, S., Wong, E.A., and Gilbert, E.R. 2015. Bioavailability of different dietary supplemental methionine sources in animals. Frontiers Biosci. 7:491-500

 

Yadgary, L., Wong, E.A., and Uni, Z. 2014. Temporal transcriptome analysis of the chicken embryo yolk sac. BMC Genomics 15:690 doi:10.1186/1471-2164-15-690.

 

Fetterer, R.H., Miska, K.B., Jenkins, M.C., and Wong, E.A. 2014. Expression of nutrient transporters in duodenum, jejunum and ileum of Eimeria maxima-infected broiler chickens.  Parasitology Res. 113:3891-3894.

 

Miska, K.B., Fetterer, R.H., and Wong, E.A. 2014. The mRNA expression of amino acid transporters, aminopeptidase N, and the di- and tri-peptide transporter PepT1 in the embryo of the domesticated chicken (Gallus gallus) shows developmental regulation.  Poult. Sci. 93:2262-2270.

 

Su, S., Miska, K.B., Fetterer, R.H., Jenkins, M.C., and Wong, E.A. 2014. Expression of digestive enzymes and nutrient transporters in Eimeria acervulina-challenged layers and broilers.  Poult. Sci. 93:1217-1226.

 

Yin, H., Zhang, S., Gilbert, E.R., Siegel, P.B., Zhu, Q., and Wong, E.A. 2014.  Expression profiles of muscle genes in postnatal skeletal muscle in lines of chickens divergently selected for high and low body weight.  Poult. Sci. 93: 147-154.

 

Paris, N.E. and Wong, E.A. 2013. Expression of digestive enzymes and nutrient transporters in the intestine of Eimeria maxima infected chickens.  Poult. Sci 92:1331-1335.

 

Zwarycz, B., and Wong, E.A. 2013. Expression of the peptide transporters, PepT1, PepT2, and PHT1 in the embryonic and post-hatch chick.  Poult. Sci. 92: 1314-1321.

Speier, J.S., Yadgary, L., Uni, Z., and Wong, E.A. 2012.  Gene expression of nutrient transporters and digestive enzymes in the yolk sac membrane and small intestine of the developing embryonic chick.  Poult. Sci. 91: 1941-1949.

 

Wu, G.Q., Siegel, P.B., Gilbert, E.R., Yang, N., and Wong, E.A.  2011.  Expression profiling of somatotropic axis genes in lines of chickens divergently selected for 56-day body weight.  Anim. Biotechnol. 22: 100-110.

 

Gilbert, E.R., Cox, C.M., Williams, P.M., McElroy, A.P., Dalloul, R.A., Ray, W.K., Barri, A., Emmerson, D.A., Wong, E.A., and Webb, K.E. Jr.  2011. Eimeria species and genetic background influence the serum protein profile of broilers with coccidiosis.  PLoS One 6: e14636.

 

Casterlow, S., Li, H., Gilbert, E.R., Dalloul, R.A., McElroy, A.P., Emmerson, D.A., and Wong, E.A.  2011. An antimicrobial peptide is downregulated in the small intestine of Eimeria maxima-infected chickens.  Poult. Sci. 90: 1212-1219.

 

Madsen, S.L. and Wong, E.A. 2011. Expression of the chicken peptide transporter one and the peroxisome proliferator-activated receptor alpha following feed restriction and subsequent refeeding. Poult. Sci. 90:2295-2300.

    Eric Wong

  • (540) 231-4737
  • (540) 231-3010 (Fax)
  • (540) 231-3183 (Lab)
  • ewong@vt.edu
  • 3150 Litton Reaves
    Blacksburg, VA 24061