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Fernando H. Biase

378 Litton Reaves Hall
www.biaselaboratory.com

Curriculum Vitae

University of São Paulo, Department of Genetics, Brazil

Doctor of Sciences (Major in Genetics and Cell Biology) April 2007

Master of Sciences (Major in Genetics) February 2003

APSC 4054 Genomics

APSC 5554 Mammalian Genome Biology

Our mission is to understand the molecular mechanisms that drive fertility and the early stages of embryo development and implantation in mammals. To achieve our goals, we are strongly committed to combining experimental, and systems genomics approaches to understand the dynamics of gene regulatory and signaling networks that orchestrate successful events related to fertility or infertility. Our efforts focus on three primary thrusts: 1) Molecular profiling of heifer infertility; 2) The acquisition of developmental competence in oocytes and the molecular signals of embryo survival; 3) Molecular communication between conceptus and endometrium.

www.biaselaboratory.com

(Since 2015)

Moorey SE, Walker BN, Elmore MF, Elmore JB, Rodning SP, Biase FH. Rewiring of gene expression in circulating white blood cells is associated with pregnancy outcome in heifers (Bos taurus). Sci Rep 10, 16786 (2020). https://doi.org/10.1038/s41598-020-73694-w.

Moorey SE, Biase FH. Beef heifer fertility: importance of management practices and technological advancements. J Anim Sci Biotechnol. 2020 Oct 1;11:97. doi: 10.1186/s40104-020-00503-9.

Walker BN, Biase FH. The blueprint of RNA storages relative to oocyte developmental competence in cattle (Bos taurus). Biol Reprod. 2020 Apr 15;102(4):784-794. doi: 10.1093/biolre/ioaa015.

Biase FH, Hue I, Dickinson SE, Jaffrezic F, Laloe D, Lewin HA, Sandra O. Fine-tuned adaptation of embryo-endometrium pairs at implantation revealed by transcriptome analyses in Bos taurus. PLoS Biol. 2019 Apr 12;17(4):e3000046. doi: 10.1371/journal.pbio.3000046.

Dickinson SE, Elmore MF, Kriese-Anderson L, Elmore JB, Walker BN, Dyce PW, Rodning SP, Biase FH. Evaluation of age, weaning weight, body condition score, and reproductive tract score in pre-selected beef heifers relative to reproductive potential. J Anim Sci Biotechnol. 2019 Feb 26;10:18. doi: 10.1186/s40104-019-0329-6.

Biase FH, Wu Q, Calandrelli R, Rivas-Astroza M, Zhou S, Zhong S. Rainbow-Seq: combining cell lineage tracking with single-cell RNA sequencing in preimplantation embryos. iScience. 2018 Sep 28;7:16-29

Biase FH, Kimble KM. Functional signaling and gene regulatory networks between the oocyte and the surrounding cumulus cells. BMC Genomics. 2018 May 10; 19(1):351.

Dickinson SE, Biase FH. Transcriptome data of peripheral white blood cells from beef heifers collected at the time of artificial insemination. Data in Brief. 2018 Jun; 18:706-709.

Kimble KM, Dickinson SE, Biase FH. Extraction of total RNA from single-oocytes and single-cell mRNA sequencing of swine oocytes. BMC Res Notes. 2018 Feb 27;11(1):155.

Dickinson SE, Griffin BA, Elmore MF, Kriese-Anderson L, Elmore JB, Dyce PW, Rodning SP, Biase FH. Transcriptome profiles in peripheral white blood cells at the time of artificial insemination discriminate beef heifers with different fertility potential. BMC Genomics. 2018 Feb 9;19(1):129.

Phillips KM, Read CC, Kriese-Anderson LA, Rodning SP, Brandebourg TD, Biase FH, Marks ML, Elmore JB, Stanford MK, Dyce PW. Plasma metabolomic profiles differ at the time of artificial insemination based on pregnancy outcome, in Bos taurus beef heifers. Sci Rep. 2018 Sep 4;8(1):13196

Biase FH. Oocyte Developmental Competence: Insights from Cross-Species Differential Gene Expression and Human Oocyte-Specific Functional Gene Networks. OMICS. 2017 Mar;21(3):156-168.

Carvalho ME, Eler JP, Bonin MN, Rezende FM, Biase FB, Meirelles FV, Regitano LCA, Coutinho LL, Balieiro JCC, Ferraz JBS. Genotypic and allelic frequencies of gene polymorphisms associated with meat tenderness in Nellore beef cattle. Genet Mol Res. 2017 Feb 16;16(1).

Biase FH, Rabel C, Guillomot M, Hue I, Andropolis K, Olmstead CA, Oliveira R, Wallace R, Le Bourhis D, Richard C, Campion, E, Chaulot-Talmon A, Giraud-Delville C, Taghouti G, Jammes H, Renard JP, Sandra O, Lewin, HA. Massive dysregulation of genes involved in cell signaling and placental development in cloned cattle conceptus and maternal endometrium. Proc Natl Acad Sci U S A. Dec 20;113(51):14492-14501.

Nguyen TC, Cao X, Yu P, Xiao S, Lu J, Biase FH, Sridhar B, Huang N, Zhang K, Zhong S. Mapping RNA-RNA interactome and RNA structure in vivo by MARIO. Nat Commun. 2016 Jun 24;7:12023.

Adona PR, Leal CL, Biase FH, De Bem TH, Mesquita LG, Meirelles FV, Ferraz AL, Furlan LR, Monzani PS, Guemra S. In vitro maturation alters gene expression in bovine oocytes. Zygote. 2016 Aug;24(4):624-33