Dr. Ealy’s laboratory conducts research in reproductive physiology. His group is interested in understanding the molecular and cellular events controlling embryo and placental development and describing how these events dictate ultimate pregnancy outcome and neonatal health.  This work targets cattle and sheep but also has relevance to human pregnancy. Major topics in Dr. Ealy’s laboratory include:

1. Embryo-uterine interactions that control events of early pregnancy;

2. Regulation of interferon-tau expression in ruminants;

3. Placental cell development and differentiation; 

4. Impact of reproductive technologies on the developmental origin of health and disease.

Cerri, R.L., Thompson, I.M., Kim, I.H., Ealy, A.D., Hansen, P.J., Staples, C.R., Li, J.L., Santos, J.E. and Thatcher, W.W. 2012. Effects of lactation and pregnancy on gene expression of endometrium of Holstein cows at day 17 of the estrous cycle or pregnancy. J. Dairy Sci. 95:5657-5675.

Pennington, K.A. and Ealy, A.D. 2012. The expression and potential function of bone morphogenetic proteins 2 and 4 in bovine trophectoderm. Reprod. Biol. Endocrinol. 10:12.

Rizos, d., Scully, S., Kelly, A.K., Ealy, A.D., Moros, R., Duffy, P., Al Naib, A., Forde, N. and Lonergan, P. 2012. Effects of human chorionic gonadotrophin administration on day 5 after oestrus on corpus luteum characteristics, circulating progesterone and conceptus elongation in cattle. Reprod. Fertil. Devel. 24:472-481.

Zhang, K. and Ealy, A.D. 2012. Disruption of fibroblast growth factor receptor signaling in bovine cumulus-oocyte complexes during in vitro maturation reduces subsequent embryonic development. Domest. Anim. Endocrinol. 42:230-238.

Silva, L.A., Klein, C., Ealy, A.D. and Sharp, D.C. 2011. Conceptus-mediated endometrial vascular changes during early pregnancy in mares: an anatomic, histomorphometric, and vascular endothelial growth factor receptor system immunolocalization and gene expression study. Reproduction 142:593-603.

Yang, Q.E., Fields, S.D., Zhang, K., Ozawa, M., Johnson, S.E. and Ealy, A.D. 2011. Fibroblast growth factor 2 promotes primitive endoderm development in bovine blastocyst outgrowths. Biol. Reprod. 85:946-953.

Yang, Q.E., Giassetti, M.I. and Ealy, A.D. 2011. Fibroblast growth factors activate mitogen-activated protein kinase pathways to promote migration in ovine trophoblast cells. Reproduction 141:617-624.

Yang, Q.E., Johnson, S.E. and Ealy, A.D. 2011. Protein kinase C delta mediates fibroblast growth factor-2-induced interferon-tau expression in bovine trophoblast. Biol. Reprod. 84:933-943.

Ealy, A.D, Eroh, M.L. and Sharp, D.C. 2010.  Prostaglandin H synthase type 2 is differentially expressed in endometrium based on pregnancy status in pony mares and responds to oxytocin and conceptus secretions in explant culture. Anim. Reprod. Sci. 117:99-105.

Klein, C., Scoggin, K.E., Ealy, A.D. and Troedsson MH.  2010. Transcriptional profiling of equine endometrium during the time of maternal recognition of pregnancy. Biol. Reprod.  83:102-113.

Pennington, K.A., Oliveira, L.J., *Yang, Q.E. and Ealy, A.D. 2010. The enrichment of trophoblast giant cells from mid-gestation bovine placentae using fluorescence-activated cell sorting. Placenta 31:738-740.  

Zhang, K., Hansen, P.J. and Ealy, A.D. 2010. Fibroblast growth factor 10 enhances bovine oocyte maturation and developmental competence in vitro.  Reproduction 140:815-826.

Ealy, A.D. and Yang, Q.E. 2009.  Control of interferon-tau expression during early pregnancy in ruminants. Am. J. Reprod. Immunol. 61:95-106.

Cooke, F.N., Pennington, K.A., Yang, Q.E. and Ealy, A.D. 2009. Several fibroblast growth factors are expressed during pre-attachment bovine conceptus development and regulate interferon-tau expression from trophectoderm.  Reproduction 137:259-269.

Rodina, T.M., Cooke, F.N., Hansen, P.J. and Ealy, A.D. 2009. Oxygen tension and medium type actions on blastocyst development and interferon-tau secretion in cattle. Anim. Reprod. Sci. 111:173-188.